Product code	Product name and quantity
8637-K001	Tissue-Tek Genie® RDA-Tag Label Kit; 1 ribbon and 2 rolls of 2,400 RDA-Tag labels; 1 kit
8616-G090	Tissue-Tek Genie® Reagent Dispense Area [RDA]; 90 RDAs; 1 box
8618-G090	Tissue-Tek Genie® Reagent Dispense Area Tag [RDA-Tag]; 90 RDA-Tags; 1 box
8636-K001	Tissue-Tek Genie® Slide Label Kit; 1 ribbon and 3 rolls of 3,000 slide labels; 1 kit
8642-G001	Tissue-Tek Genie® Storage and Transport Tray, Blue; 1 unit
8641-G001	Tissue-Tek Genie® Storage and Transport Tray, Red; 1 unit
8217-G004	Tissue-Tek Genie® Waste Bottles
8643-G001	Tissue-Tek Genie® Workflow Organizer; 1 unit
9036	Tissue-Tek® SmartWrite® White Frosted Slides - Charged; 100/box; 10 boxes/case
9046	Tissue-Tek® SmartWrite® Blue Frosted Slides - Charged, 100/box; 10 boxes/case
9048	Tissue-Tek® SmartWrite® Green Frosted Slides - Charged, 100/box; 10 boxes/case
9050	Tissue-Tek® SmartWrite® Lavender Frosted Slides - Charged, 100/box; 10 boxes/case
9052	Tissue-Tek® SmartWrite® Pink Frosted Slides - Charged, 100/box; 10 boxes/case
9054	Tissue-Tek® SmartWrite® Yellow Frosted Slides - Charged, 100/box; 10 boxes/case
9809-G006	Tissue-Tek Genie® CISH User-Fillable Cartridges for CISH Amplification Linker; 6 cartridges/box
8610-K050	Genie® User-Fillable Capsule Sealing System; 1 kit
8622-G006	Tissue-Tek Genie® User-Fillable Cartridge for Biomarker-Binding Reagent, 6 cartridges/box; 1 box
8611-G002	Tissue-Tek Genie® User-Fillable Capsule Tray, 2/box; 1 box
8615-G001	Tissue-Tek Genie® User-Fillable Capsule Sealer; 1 unit
8619-K100	Tissue-Tek Genie® User-Fillable Capsules and Seals, 100 capsules, 130 seals; 1 kit

The innovative single-use Capsules make Genie the most convenient stainer on the market, eliminating batching and sorting of slides, and giving you the flexibility to load any slide, any stain, any time, any station on any Genie.



Benefit from using Capsules:
1. Run cases or single slides without the need to batch slides by antibody
2. Save time loading slides whenever a staining station is available
3. Use for any slide volume of any biomarkers

The capsule is mounted to the Tissue-Tek Genie^® Reagent Dispense Area (RDA) with its attached protocol RDA-Tag and both are loaded into an empty stain station.



In summary, this innovative technology enables laboratories to quickly load slides and reagents for an IHC stain to gain continuous workflow with short and predictable TAT.

 

Tissue-Tek Genie^® Pro Detection Kit, DAB

Product code and quantity

8826-K250: 6 cartridges, 250 tests, RTU; 1 kit

Description

The Tissue-Tek Genie Pro Detection Kit, DAB uses a non-biotin based system to detect and to visualize mouse or rabbit primary antibodies bound to antigens in Formalin-Fixed, Paraffin-Embedded (FFPE) specimen sections.

The detection system uses Protein and Peroxidase blocks to prevent unspecific binding of antibodies to antigens and reactions of endogenous peroxidase with downstream components of the detection system. After blocking, the detection system uses a Link solution that binds to the mouse or rabbit primary antibodies to form a complex with a horse radish peroxidase (HRP) conjugate which increases sensitivity.

The complex is then visualized with the addition of DAB. DAB Intensifier can be used to increase the intensity of
DAB staining.

Components

The detection system kit contains 6 cartridges, one cartridge each of the following:
• Tissue-Tek Genie® Protein Block, 250 tests
• Tissue-Tek Genie® Peroxidase Block, 250 tests
• Tissue-Tek Genie® Link, 250 tests
• Tissue-Tek Genie® Poly HRP-Conjugate, 250 tests
• Tissue-Tek Genie® DAB, 250 tests
• Tissue-Tek Genie® DAB Intensifier, 250 tests



These 6 images display the exceptional sensitivity (high dynamic range) and superb specificity (no visible non-specific background staining) of the Tissue-Tek Genie Pro Detection Kit, DAB and selected Tissue-Tek Genie antibodies.

Positive Helicobacter pylori staining in crypts of gastric mucosa, no background staining.	Negative staining of colon adenocarcinoma with loss of MLH1 expression, no background staining.	Negative staining of colon adenocarcinoma with loss of MSH2 expression, no background staining.
Negative staining of colon adenocarcinoma with loss of MSH6 expression, no background staining.	Negative staining of colon adenocarcinoma with loss of PMS2 expression, no background staining.	CK 19 staining in crypt cells of appendix with high dynamic range, no background staining.

The Tissue-Tek Genie Pro Detection Kit, DAB HRP staining steps provide standardization using RTU components and timing flexibility where needed.


 

Tissue-Tek Genie^® Pro AP Red Detection Kit

Product code and quantity

8836-K250: 4 cartridges, 250 tests, RTU; 1 kit

Description

The Tissue-Tek Genie Pro AP Red Detection Kit uses a
non-biotin based system to detect and to visualize mouse and rabbit primary antibodies bound to antigens informalin-fixed, paraffin-embedded (FFPE) specimen sections.

The detection system uses protein block to prevent nonspecific binding of antibodies to antigens with downstream components of the detection system. After blocking, the detection system uses a link solution that binds to the mouse and rabbit primary antibodies to form a complex with an alkaline phosphatase AP-Conjugate. The complex is then visualized with the addition of AP Red.

Components

The detection system kit contains 4 cartridges, one cartridge each of the following:
• Tissue-Tek Genie® Protein Block
• Tissue-Tek Genie® Link
• Tissue-Tek Genie® Poly AP-Conjugate
• Tissue-Tek Genie® AP Red



These 3 images display the exceptional sensitivity (high dynamic range) and superb specificity (no visible non-specific background staining) of the Tissue-Tek Genie Pro AP Red Detection Kit and selected Tissue-Tek Genie antibodies.
 

Strong pan melanoma staining of melanoma.	Melan-A staining of blue nevus.	SOX10 staining of melanoma.

The Tissue-Tek Genie Pro AP Red Detection Kit, staining steps provide standardization using RTU components and timing flexibility where needed.



 

Tissue-Tek Genie^® DUO Detection Kit

Product code and quantity

8837-K250: 6 cartridges, 250 tests, RTU; 1 kit

Tissue-Tek Genie® DUO Mouse-DAB/Rabbit-AP Red Dual Detection Kit

The Tissue-Tek Genie® DUO Mouse-DAB/Rabbit-AP Red Dual Detection Kit uses a non-biotin-based system to detect and to visualize mouse and rabbit primary antibodies bound to antigens in FFPE specimen sections.
The detection system uses a protein block to prevent nonspecific binding of antibodies to antigens with downstream components of the detection system. After blocking, mouse and rabbit primary antibodies are applied on the tissue sections simultaneously using prefilled capsules or cartridges. Subsequently, the detection system sequentially applies the Link Mouse solution that binds to mouse primary antibodies and then the Link Rabbit solution that binds to rabbit primary antibodies. This is followed by an application of a cocktail containing a horseradish peroxidase (HRP) conjugate for mouse and an alkaline phosphatase AP-Conjugate for rabbit. The resulting complex is visualized by sequentially applying the diaminobenzidine (DAB) substrate-
chromogen solution, and then by applying the AP Red substrate-chromogen solution, which create colored precipitates at the location of the antigens.




 

Tissue-Tek Genie® DUO anti-Melan-A [EP43] /Ki67 [GM010] Antibody Cocktail. Note that the benign melanocytes are not proliferatively active.	Tissue-Tek Genie® DUO anti-Pan Cytokeratin [AE1/AE3/DC10] / CD31[RM247] Antibody Cocktail. The combination of these two markers on a single slide is particularly helpful for identifying small foci of carcinoma within lymphatics.	Tissue-Tek Genie® DUO Non-immune Mouse and Rabbit Ig Antibody Cocktail.

 

Tissue-Tek Genie^® Pro Antibody Diluent

Product code and quantity

8866-G004: RTU, 4 bottles, 100 mL each; 1 case

Description

Optimal staining performance during immunohistochemistry (IHC) is achieved through dilution of the primary antibodies. This dilution process involves mixing concentrated antibody with Tissue-Tek Genie^® Pro Antibody Diluent to an optimal dilution determined by the user. The diluted antibody can then be filled into a Tissue-Tek Genie^® User-Fillable Capsule, Tissue-Tek Genie^® User Fillable Cartridge, or be applied by hand during manual application mode on the Tissue-Tek Genie® Advanced Staining System.

Tissue-Tek Genie^® Hematoxylin

Product code and quantity

8830-M250: RTU, 250 tests, 1 cartridge: 1 unit

Description

The Tissue-Tek Genie^® Hematoxylin is designed to counterstain cellular nuclei in formalinfixed, paraffin embedded (FFPE) human specimen sections after immunohistochemistry (IHC) staining of specific protein targets or chromogenic in situ hybridization (CISH) of specific DNA or RNA targets using the automated Tissue-Tek Genie^® Advanced Staining System.
 

Tissue-Tek Genie^® Citrate Antigen Retrieval Solution

Product code and quantity

8742-G001: RTU, 1 bottle, 3.8 Liters; 1 unit

Description

Tissue-Tek Genie^® Citrate Antigen Retrieval Solution is designed for heat-induced epitope retrieval (HIER) of specimen sections during immunohistochemical (IHC) staining on the Tissue-Tek Genie® Advanced Staining System.

Tissue fixation involves creating crosslinks between protein residues in the tissue. This fixation process preserves the tissue, but also denatures many antigens and makes antigen sites within the tissue less accessible to antibodies. The Tissue-Tek Genie Citrate Antigen Retrieval Solution is applied to the specimen section and heated on the Tissue-Tek Genie Advanced Staining System. This process breaks the crosslinks formed during fixation and allows proteins to renature which allows greater accessibility of antigenic sites to antibodies.

Tissue-Tek Genie^® Dewax Solution

Product code and quantity

8865-G001: RTU, 1 bottle, 3.8 Liters; 1 unit

Description

Tissue-Tek Genie^® Dewax Solution is designed to remove paraffin wax from paraffin embedded tissue sections on the Tissue-Tek Genie^® Advanced Staining System.

Formalin-fixed, paraffin embedded (FFPE) specimen sections mounted on microscope slides are treated with Tissue-Tek Genie Dewax Solution on the Tissue-Tek Genie Advanced Staining System prior to the immunohistochemistry and/or in situ hybridization staining processes. Specimen sections in the presence of Tissue-Tek Genie Dewax Solution are gently heated for optimized removal of paraffin.

Tissue-Tek Genie^® High pH Antigen Retrieval Solution

Product code and quantity

8744-G001: RTU, 1 bottle, 3.8 Liters; 1 unit

Description

Tissue-Tek Genie^® High pH Antigen Retrieval Solution is designed for heat-induced epitope retrieval (HIER) of specimen sections during immunohistochemical (IHC) staining on the Tissue-Tek Genie^® Advanced Staining System.

Tissue-Tek Genie^® Wash Buffer Solution

Product code and quantity

8874-G004: RTU, 4 bottles, 3.8 Liters each: 1 case

Description

Tissue-Tek Genie^® Wash Buffer Solution is designed to remove residual reagents from tissue sections during immunohistochemical (IHC) staining on the Tissue-Tek Genie^® Advanced Staining System.

The Tissue-Tek Genie Wash Buffer Solution is a bulk reagent that is used between incubation steps during IHC or ISH staining processes. The Tissue-Tek Genie Wash Buffer Solution serves as a rinsing agent for the removal of residual reagents that remain on the tissue sections from the previous protocol step.

Tissue-Tek Genie^® Proteinase K

Product code and quantity

9811-M100: RTU, 100 tests, 1 cartridge; 1 unit

Description

The Tissue-Tek Genie^® Proteinase K is intended for the proteolytic digestion of formalin-fixed, paraffin embedded (FFPE) human tissue sections during immuno-histochemistry (IHC) staining of specific protein targets or chromogenic in situ hybridization (CISH) staining of specific DNA or RNA targets on the automated Tissue-Tek Genie^® Advanced Staining System.