Clone: EP324
Host clonality: rabbit monoclonal
Control tissue: tonsil, appendix, liver, CD163 positive dermatofibromas
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
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Product code:
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8245-C010: RTU, 10 capsules; 1 pack
8245-M250: RTU, 250 tests, 1 cartridge; 1 unit
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CD163 is a membrane protein that has anti-inflammatory functions and is expressed by cells of the monocyte/macrophage lineage. It is found in a majority of acute myeloid leukemia cases with monocytoid differentiation and histiocytic sarcoma.
Macrophages of the lamina propria and submucosa of this appendix show a strong cytoplasmic reaction for CD163, while other tissue elements are negative
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Weak to moderate granular cytoplasmic reactivity for CD163 is seem among germinal center macrophages. Strong reactivity is seen in the macrophages of the interfollicular regions. The lymphocytes of the follicle and perifollicular areas of this tonsil are negative.
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Renal tissues, including glomeruli, ducts and tubules, are negative for CD163, while scattered macrophages cells show moderate to strong cytoplasmic reactivity.