Clone: GM016
Host clonality: mouse monoclonal
Control tissue: appendix, liver, ductal breast carcinoma
Staining pattern: membraneous
Regulatory status: IVD, FDA Class I
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Product code:
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8229-C010: RTU, 10 capsules; 1 pack
8229-M250: RTU, 250 tests, 1 cartridge; 1 unit
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E-cadherin is a transmembrane cell adhesion glycoprotein that is critical for epithelial junction formation. E-cadherin is expressed in a majority epithelial cells.
Strong membraneous staining is observed in the colonic epithelium and is absent in the stromal cells.
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Moderately strong membrane staining is seen in the hepatocytes, while strong staining is observed in the bile ducts.
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This image demonstrates negative E-Cadherin staining among the infiltrating lobular carcinoma cells in the breast stroma, as well as in the in situ component.