Clone: RM116
Host clonality: rabbit monoclonal
Control tissue: tonsil, lymph node or selected B-cell neoplasms
Staining pattern:
Regulatory status: IVD, FDA Class I
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Product code:
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8383-C010: RTU, 10 capsules; 1 pack
8383-M250: RTU, 250 tests, 1 cartridge; 1 unit
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In normal healthy serum, IgG is the most abundant of the Ig classes. Igs are produced in mature B-cells and plasma cells, and the amount and type of Ig can vary in different stages of B-cell maturation: in the earlier stages of maturation, Igs are present in the cytoplasm, whereas surface expression of Igs is more characteristic of mature B-cells in the mantle zone.
In the germinal centers of tonsil and lymph nodes, a strong staining reaction for IgG is observed in the cytoplasm of plasma cells, and weak to moderate staining in the cytoplasm and membrane of immunoblasts in the germinal centers.
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Neural and glial elements in the cerebrum show no staining reaction for IgG, while some staining is observed in vessel lumens.