Tissue-Tek Genie®
anti-Cytokeratin 8

Clone: EP17
Host clonality: rabbit monoclonal
Control tissue: liver, gastrointestinal tract, and known CK8 positive tumors
Staining pattern: cytoplasmic and sometimes membraneous
Regulatory status: IVD, FDA Class I
Product code: 8238-C010: RTU, 10 capsules; 1 pack
8238-M250: RTU, 250 tests, 1 cartridge; 1 unit

 

Cytokeratin 8 (CK8) is low molecular weight cytokeratin that is often co-expressed with cytokeratin 18. Cytokeratin 8 is expressed in simple, non-stratified epithelia, in transitional epithelium, and in the luminal/secretory cells of complex epithelia.
Tissue-Tek Genie<sup>&reg;</sup><br/> anti-Cytokeratin 8 Strong membraneous and cytoplasmic reactivity for CK8 is seen among the columnar epithelial cells of the appendix.

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Weak to moderate cytoplasmic and membraneous staining for CK8 is seen in normal hepatocytes, with stronger staining among the hepatocytes of periportal areas.

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The simple epithelium of these glands show strong membraneous and cytoplasmic CK8 reactivity, while the overlying squamous epithelium shows only weak reactivity in the basal aspect.
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