Tissue-Tek Genie® DUO
anti-Pan Cytokeratin/CD31 Antibody Cocktail

Clone: (AE1/AE3/DC10)/RM247
Host clonality: mouse and rabbit monoclonal
Control tissue: tonsil, appendix, liver, carcinoma
Staining pattern: cytoplasmic and some membraneous staining for cytokeratins and membraneous and cytoplasmic staining for CD31
Regulatory status: IVD, FDA Class I
Product code: 8484-C010: RTU, 10 capsules; 1 pack
8484-M100: RTU, 100 tests, 1 cartridge; 1 unit

 

Cytokeratins (CK) are a group of intermediate filament proteins expressed in cells of epithelial origin. CD31, also known as platelet/endothelial cell adhesion molecule 1 (PECAM-1), is a transmembrane protein expressed on endothelial cells and is considered to be a pan-endothelial cell marker.
Tissue-Tek Genie<sup>&reg;</sup> DUO<br /> anti-Pan Cytokeratin/CD31 Antibody Cocktail Moderate to strong cytoplasmic and membraneous reactivity for cytokeratins, in brown, is seen among collecting duct epithelial cells and parietal epithelial cells of Bowman’s capsule. Moderate to strong cytoplasmic reactivity for CD31,
in red, is seen among endothelial cells of glomeruli
and within larger vessels.

2-(1).jpg
Moderate to strong cytoplasmic and membraneous reactivity for cytokeratins, in brown, is seen among hepatocytes. Moderate to strong cytoplasmic reactivity for CD31, in red, is seen among sinusoidal endothelial cells.

3-(1).jpg
o brown cytoplasmic reactivity for cytokeratins is seen in this cerebrum, while endothelial cells of small vessels show strong red cytoplasmic and membrane reactivity for CD31.
Back to top