Tissue-Tek Genie®
anti-IgM

Clone: polyclonal
Host clonality: rabbit polyclonal
Control tissue: tonsil, lymph node, or selected B-cell neoplasms
Staining pattern: membraneous and cytoplasmic
Regulatory status: IVD, FDA Class I
Product code: 8385-C010: RTU, 10 capsules; 1 pack
8385-M250: RTU, 250 tests, 1 cartridge; 1 unit

 

In normal, healthy serum IgM is generally the third most abundant of the immunoglobulin heavy-chain classes. Immunoglobulin (Igs) are produced in mature B-cells and plasma cells, and the amount and type of Ig can vary in different stages of B-cell maturation: Igs in the earlier stages of maturation are present in the cytoplasm, whereas surface expression is more characteristic of mature B-cells in the mantle zone.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-IgM The B-cells of the germinal centers show moderate to strong cytoplasmic expression of IgM and the mantle zone B-cells show a moderate to strong membrane staining reaction.

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As is typical of most tissues, weak to moderate IgM staining is seen in the extracellular spaces of the mucosa and submucosa of the esophagus.

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The islets, pancreatic acinar cells and bile ducts are negative for IgM expression. Background IgM reactivity is seen in vessel lumens and extracellular spaces.
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