Clone: EP156
Host clonality: rabbit
Control tissue: tonsil, appendix, B-cell lymphoma
Staining pattern: nuclear
Regulatory status: IVD, FDA Class I
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Product code:
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8500-C010: RTU, 10 capsules; 1 pack
8500-M250: RTU, 250 tests, 1 cartridge; 1 unit
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PAX5, also designated B-cell specific activator protein (BSAP), is a transcription factor of the paired-box (PAX) containing family. PAX5 is important in control of B-cell commitment and shows nuclear expression in early progenitor B-cells and in all mature B-cells.
Strong diffuse nuclear staining of PAX5 is observed in B-cells of the germinal centers, mantle zones, and inter-follicular areas of the tonsil, while T-cells and squamous epithelium are negative.
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The PAX5 antibody highlights Hodgkins cells with moderate to strong nuclear and weak cytoplasmic staining. The background non-neoplastic B-cells are strongly positive for nuclear PAX5 reactivity.