Clone: HMB45/EP43/T311
Host clonality: mouse and rabbit monoclonal
Control tissue: skin, melanoma, adrenal gland
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
Product code:
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8371-C010: RTU, 10 capsules; 1 pack
8371-M250: RTU, 250 tests, 1 cartridge; 1 unit
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PMEL17, MART-1 and tyrosinase are proteins expressed in normal melanocytes, and are often detected in melanomas.
The pan-melanoma antibody cocktail demonstrates strong cytoplasmic reactivity among intra-epithelial melanocytes and the cells of this blue nevus. No staining is seen within the squamous epithelium, stromal fibroblasts or endothelial cells. (Alkaline Phosphatase Red detection).
Weak to moderate cytoplasmic staining is seen in the adrenal gland. (Alkaline Phosphatase Red detection).