Clone: EP151
Host clonality: rabbit monoclonal
Control tissue: bone marrow, tonsil, liver, and myeloid leukemias
Staining pattern: granular cytoplasmic
Regulatory status: IVD, FDA Class I
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Product code:
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8407-C010: RTU, 10 capsules; 1 pack
8407-M250: RTU, 250 tests, 1 cartridge; 1 unit
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Myeloperoxidase (MPO) is a peroxidase enzyme involved in antimicrobial activity. MPO is synthesized and expressed in precursor and mature granulocytes, including neutrophils and eosinophils, and is variably expressed in monocytes/macrophages.
The neoplastic cells of this example of acute myeloid leukemia (AML-M1) involving bone marrow, show diffuse strong granular cytoplasmic reactivity for MPO.
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The neoplastic cells of this mantle cell lymphoma show no reactivity for MPO.
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Hepatocytes show no, or only weak, cytoplasmic granular staining for MPO. Kupffer cells are strongly positive for a granular cytoplasmic staining reaction.