Clone: GM007
Host clonality: mouse monoclonal
Control tissue: intestine
Staining pattern: cytoplasmic
Regulatory status: IVD, FDA Class I
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Product code:
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8311-C010: RTU, 10 capsules; 1 pack
8311-M250: RTU, 1 cartridge, 250 tests; 1 unit
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Desmin is an intermediate filament of all three types of muscle cells (skeletal, cardiac, and smooth muscle). Desmin is also expressed in myofibroblasts and mesothelial cells but is absent in myoepithelial cells, malignant mesothelioma, and adenocarcinoma. Desmin is expressed in the majority of rhabdomyomas, leiomyomas, rhabdomyosarcomas, and leiomyosarcomas.
Negative staining of the glandular epithelium but moderate staining in smooth muscle cells of leiomyoma, also known as fibroid.
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Strong staining in smooth muscle cells in muscularis propria of appendix.
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Moderate staining in round and spindle cells of rhabdomyosarcoma.