Tissue-Tek Genie®
anti-Lambda Light Chains

Clone: polyclonal
Host clonality: rabbit polyclonal
Control tissue: tonsil, lymph node, and lambda light chain protein positive B-cell neoplasms
Staining pattern: membraneous and cytoplasmic
Regulatory status: IVD, FDA Class I
Product code: 8398-C010: RTU, 10 capsules; 1 pack
8398-M250: RTU, 250 tests, 1 cartridge; 1 unit

 

Amounts and types of immunoglobulin (Ig) monomers can vary in different stages of B-cell maturation. Igs are expressed in the cytoplasm (early stage of maturation, plasma cells) or membrane (B-cells in the mantle zone). Neoplasms such as B-cell lymphoma and plasma cell myeloma may be demonstrated to be clonal when they produce only one type of Ig light chain.
Tissue-Tek Genie<sup>&reg;</sup><br /> anti-Lambda Light Chains Strong cytoplasmic and membraneous staining for lambda light chain is seen in a subset of plasma cells in this germinal center. Light background staining is also seen due to extracellular immunoglobulin deposition.

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Moderately strong cytoplasmic lambda light chain expression is detected in this case of CLL/SLL.
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