Clone: 5B10
Host clonality: mouse monoclonal
Control tissue: tonsil, spleen, selective ALCL
Staining pattern: granular cytoplasmic
Regulatory status: IVD, FDA Class I
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Product code:
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8236-C010: RTU, 10 capsules; 1 pack
8236-M250: RTU, 250 tests, 1 cartridge; 1 unit
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Perforin is a key molecule for cytotoxicity mediated by T-cells and natural killer cells. It is expressed in the cytoplasmic granule of cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and is a specific marker of functionally active CTLs and NK-cells.
Numerous dispersed benign cytotoxic T-cells show moderate to strong granular reactivity for perforin in this example of a “high expresser” tonsil.
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Weak to moderate granular cytoplasmic reacitivity is seen for perforin in this example of a peripheral T-cell lymphoma infiltrating bone marrow.
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There is no reactivity for perforin in this B-cell chronic lymphocytic lymphoma. Rare cytotoxic T-cells are positive for granular cytoplasmic reactivity.