Publications

Immunohistochemical Expression Profiles of PRAME in Human Normal FFPE Tissue Spe...

PRAME (PReferentially expressed Antigen in Melanoma), is a member of the Cancer Testis Antigen (CTA) gene family, which has been detected in various tumors by Northern Blot, RT-PCR, and IHC. PRAME is commonly used as ...

Comparative Analysis of a New IHC Assay for PD-L1 Expression in Non-Small Cell L...

Lung cancer is one of the leading causes of cancer-related mortalities globally and especially the United States. The level of Program Death Ligand-1 (PD-L1) IHC expression is used ...

Automated Robust Image Analysis Qualifying H&E Staining Adequacy with Varying He...

Inconsistencies in H&E staining protocols are a well recognized feature across different histopathology laboratories. The aim of the study was to validate an automated image analysis system (IAS) to qualify H&E staining adequacy with varying ...

Image analysis found no statistically significant differences in image quality o...

No statistically significant differences in brightness, sharpness, and contrast between Film- and Glass-coverslipped slides were found.

IHC Optimization of SARS-CoV2 (COVID-19) Virus Spike Protein Antibody using Tiss...

The preliminary data suggest that the optimized protocol using anti-SARS-CoV-2 antibody [1A9] with the Tissue-Tek Genie Advanced Staining System may be useful for the detection of multiple variants of the SARS-CoV-2. However, testing of more samples ...

IHC Comparative Analysis of HER2 Clones on Invasive Intraductal Carcinomas

HER2 EP3 performs similarly to 4B5

Anatomical Pathology Patient Interest Association (APPIA) TOPS Tissue Handling G...

The TOPS guidelines are separated into the ten (10) main sequential steps of the pre-analytical process and list the industry best practices related to each step. The ten primary steps include tissue specimen labeling, tissue specimen ...

800,000 slides show Film helped to dramatically cut down on scanning errors

To prevent interference with the mechanical elements of the scanning system and unnecessarily increase scanning time, glass slides need to be clean and free of artifacts, and coverslips have to be placed carefully, well-aligned and free of excess mou...

Unlocking the mystery of an effective tissue processing protocol

Having an efficient tissue processing protocol is crucial for multiple reasons. With its upstream positioning in the histology process, inefficient tissue processing can have negative ramifications through the rest of the downstream process from embe...

Evaluation of two eco-friendly neutralizers for a spectrum of tissue fixatives f...

Formaldehyde is a widely used aldehyde in biomedical applications, including tissue fixation. It is this same fixative property that can result in toxicity if aldehydes are improperly discarded. A proper neutralization of aldehyde waste pro...

Conventional versus Tissue-Tek Xpress® x120 Rapid Tissue Processing

Conventional tissue processing instruments have traditionally been the primary option to effectively process large surgical tissue samples. Under a traditional conventional process, tissues are grossed during the day, then held and processed in large...

No difference in scan speed and stain quality comparing Film vs. glass coverslip...

It is important to know if there is a difference in scanning speed and stain quality captured by imaging, when coverslipping slides with Film or glass.

Reducing common embedding errors through automation: Manual embedding versus au...

Until the last decade, tissue embedding has been performed using a manual process. At grossing, tissues are described and often inked for orientation and dissected before being placed into a cassette for tissue processing.

Use of Ozone for Inactivation of Bacteria and Viruses in Cryostats

In cryotomy, the risk of transmittance of health-care associated pathogens from tissue samples and surfaces is of particular concern. For optimal staff protection, it is often desirable to reduce the risk of contamination by a simple disinfection rou...

After 10 years of storage, significantly fewer artifacts are seen in Film-covers...

Common practices among U.S. clinical hospitals and reference laboratories is that slides have to be stored for a minimum of 10 years so they can be retrospectively reviewed any time, on-demand. While glass was traditionally used for coverslipping, ov...

BRAF Mutation Cross-Contamination Is Not Identified In A Large Series Of Slides ...

An increasing number of molecular diagnostic tests are performed on patient tissue scraped from glass slides sectioned on a manual microtome. In the case of RNA-based assays, extensive cleaning of instruments and apparatus are undertaken to prevent c...

A Minimally Invasive Method (Liquid Biopsy) Enabling Detection of Rare Cells usi...

Whole blood, serving as a “liquid biopsy”, can provide a means of monitoring the status of a cellular or tissue-based event (e.g. cancer) using a minimally invasive needle stick of the patient.

Improving the Yield of Cell Deposition onto Glass Slides to Detect Target Cells

The cytocentrifugation protocol for depositing cells from a suspension onto glass slides requires maximal cell yield and highest recovery rate to detect target cells. These deposited cells need to retain their cellular integrity for cell or biomarker...

Continuous Specimen Flow Changes Night Shifts to Day Shifts While Reducing Turn-...

To reduce average TAT from 36-42 hours to 24-26 hours, the laboratory was restructured to include, relocation and a new floor plan for linear specimen workflow with a larger workspace. Conventional tissue processors were replaced with continuous flow...

Cost-Effectiveness Of Remote Live Digital Imaging For Intraoperative Consults Us...

More hospitals are establishing centralized frozen laboratories on-campus and/or at satellite facilities creating the need to provide Pathologists instant remote access to frozen section slides for review from their office for live intraoperative con...

Liquid Biopsy: A Minimally Invasive Method Enabling Prenatal or Cancer Diagnosti...

A minimally invasive method of monitoring disease status before, during and after treatment benefits both patient and physician. Whole blood serving as a “liquid biopsy” can provide a means of monitoring the status of an event (e.g. pregn...

Tissue-Tek SmartSection® The First Random Access, Fully Automated Robotic Microt...

Sectioning is the most important and challenging technical skill of Histotechnologists. Producing quality slides with consistent section thickness without tears, wrinkles and folds is critical for Pathologists to make a diagnosis and for image analys...

A Simple Tool For Securing Tissue Orientation and Standardizing Tissue Location:...

One of the challenges that Histologists face is orienting tissues and locking the orientation of small biopsies and core tissue punches during manual embedding. If not orientated correctly, the subsequent sections are not adequate for the Pathologist...

ROBOTIC AND SEMI‐AUTOMATED MICROTOMY CAN DECREASE VARIABILITY IN HER2 STAINING ...

Advancements in targeted therapeutics demand increasingly quantitative evaluation of biomarker expression in prognostic and predictive assays. Calibration of such assays is critical for accurate results. Pre‐analytic variables, such as section thickn...

Locking Tissue Orientation from Grossing Through Review with Tissue-Tek® Parafor...

Pathologists, Pathologist Assistants, and Histologists are challenged with orienting and locking small tissue specimens in cassettes at grossing and embedding. If not oriented correctly, the tissue sections may not be adequate for the Pathologist to ...

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